At what blood pressure is Papaverine prescribed?

Release form and composition

The international non-proprietary name of the product is Papaverine, in English Papaverine, in Latin Papaverinum. In the form of hydrochloride, the chemical name is 1-[(3,4-dimethoxyphenyl) methyl]-6,7-dimethoxyisoquinoline.

Papaverine hydrochloride for blood pressure is available in 3 dosage forms:

• solution for injection 20 mg/ml;
• rectal suppositories weighing 2 g with an active substance content of 20 mg;
• tablets for children from one year old 10 mg, for adults 40 mg.

In addition to the active substance, the solution for injection contains disodium edetate, DL-methionine, and water for injection. 10 glass ampoules with a volume of 2 ml are packed in cardboard boxes with a leaflet containing detailed instructions for use. Additionally, the package may contain a paper or polyvinyl chloride insert for ampoules.

Suppositories are packaged in 10 pcs., the excipients include semi-synthetic glycerides in the amount necessary to make a suppository weighing 2.0 g. Papaverine tablets for pressure are sold in cardboard boxes with strip packaging of 10, 20, 30, 50 or 100 pcs.

Papaverine - how to take with high blood pressure

Date updated: 09/07/2019
When your blood pressure suddenly rises and nausea and dizziness occur, you need to act quickly and consciously.

In this case, doctors recommend that patients always have Papaverine tablets with them for high blood pressure.

This is a time-tested antispasmodic that relaxes muscles and relieves vascular tone.

It allows you to bring the patient to a normal state and help him survive the next surge in pressure.

Letters from our readers

Indications for use

The medicine is prescribed in the following cases:

• high blood pressure;
• hypertensive crisis;
• bronchospasm;
• spasms in the gastrointestinal tract;
• spasms of cerebral vessels;
• cardiac ischemia.

The drug is available in the form of tablets, ampoules and suppositories. Depending on the diagnosis, the form of medication is selected.

Effect on blood pressure

For hypertension, Papaverine is prescribed to improve the patient’s well-being and temporarily reduce blood pressure. The drug does not provide any treatment as such.

The medicine contains papaverine hydrochloride, which is produced by processing poppy straw. This is a natural drug that is not addictive and has minimal side effects.

The active substance relieves the tone of the walls of blood vessels and dilates them. This helps lower blood pressure for a period of time.

Papaverine should not be taken on an ongoing basis to lower blood pressure. Doctors recommend not using it for more than 3 days.

If during this time the pressure has not returned to normal, a course of treatment should be prescribed aimed at strengthening the blood vessels and heart.

Instructions for use

When blood pressure increases, a Papaverine injection is used. It is often used in conjunction with Dibazol, which has an identical effect on the body. This helps to quickly reduce blood pressure and avoid a hypertensive crisis.

Tablets with suppositories are also effective, but they do not act as quickly. If there is no threat of a hypertensive crisis, you can use these forms of release.

After administration of the drug, drowsiness may occur, so the patient should spend several minutes in a calm position.

Dosage of the drug for adult patients:

• ampoules – 2 ml 2-4 times a day;
• tablets – 40-60 mg 3-4 times a day;
• rectal suppositories – 20-40 mg 2 times a day.

The drug is available in every home medicine cabinet. Therefore, knowing in what dose and at what pressure to take Papaverine, you can quickly help a loved one.

Side effects

The drug is well tolerated by patients with hypertension. It causes almost no side effects or intolerances.

Rarely observed:

• disruption of the digestive system;
• itching and rash on the skin;
• yellowing of the skin;
• heart rhythm disturbance;
• drowsiness;
• sweating;
• blood clot formation;
• hypotension.

The occurrence of side effects indicates that the drug is not suitable for the patient. It should be replaced with a medicine with the same effect, but with a different composition.

Contraindications

Papaverine should not be used in the following cases:

• adrenal insufficiency;
• traumatic brain injuries;
• dysfunction of the thyroid gland;
• BPH;
• glaucoma;
• liver and kidney diseases;
• tachycardia;
• bradycardia;
• intolerance to the active substance;
• children up to 6 months;
• adult age after 65 years.

Special instructions are given in the instructions for pregnant women and nursing mothers. No studies have been conducted on whether Papaverine increases or decreases blood pressure in a fetus or newborn. Therefore, you should not treat yourself.

The medicine is often used when there is a threat of miscarriage, as it relieves the tone of the uterus. However, no negative effects on the fetus were recorded.

If a woman has very high blood pressure, whether to prescribe the drug or not is decided by the doctor who is caring for the pregnancy.

Overdose

To lower blood pressure, papaverine should be taken in the doses strictly specified in the instructions. Excess may lead to apathy, development of atrioventricular block, and cardiac arrest.

If the patient has taken a large amount of the drug, he should rinse his stomach and drink the sorbent. Those around you need to be ready to provide first aid.

Interaction with other drugs

Drinking alcohol and smoking reduces the effectiveness of the drug. Moreover, combining it with alcohol can lead to fainting.

Taking the medicine together with Levodopa and Methyldopa reduces their effect.

Simultaneous treatment with barbiturates, Analgin, Diclofenac, tricyclic antidepressants, Procainamide, Reserpine, Quinidine or Diphenhydramine enhances the effectiveness of Papaverine to lower blood pressure.

The antibiotic Furadoninre with an antispasmodic can lead to hepatitis.

Anticholinergics begin to act much more effectively if both drugs are taken simultaneously.

Combined treatment with a synthetic analogue of natural prostaglandin E1 leads to such trouble as priapism.

Combination with cardiac glycosides increases myocardial contractility.

Analogs

There are a large number of drugs that can replace Papaverine for high blood pressure.

Papazole – contains bendazole papaverine, relieves spasms and dilates blood vessels. It should not be taken in case of individual intolerance, impaired AV conduction, epilepsy, bronchial obstruction syndrome, depressed breathing and under 12 months of age.

Andipal - contains several active substances: bendazole, metamizole sodium, papaverine and phenobarbital. Contraindications include pathology of the liver and kidneys, G6PD deficiency, blood diseases, increased susceptibility to substances in the composition.

No-spa - contains drotaverine hydrochloride. Not recommended for renal and liver dysfunction, low cardiac output syndrome, individual intolerance to drotaverine, impaired galactose metabolism, lactose deficiency, in children under 12 months of age.

Bellaverine – contains papaverine and belladonna. The medicine should not be taken in case of hypersensitivity to active substances, angle-closure glaucoma, pathological enlargement of the prostate gland, heart rhythm disturbances with frequent atrial contractions, under the age of 12 months.

Pagluferal – active ingredients: bromoisal, calcium gluconate, caffeine, papaverine, phenobarbital. It is not recommended to take if you have individual intolerance to the components, kidney or liver failure.

Each of the analogues affects patients individually. Whether Papaverine lowers blood pressure better than them can only be found out by trying it.

Recommendations

Elderly patients and those with poor health should use the medicine in reduced doses. During treatment, you need to be observed by a doctor in order to notice a deterioration in your health in time.

This rule also applies to patients with traumatic brain injury, disorders of the kidneys and liver, decreased thyroid function, tachycardia or shock.

The drug is not able to cure hypertension, it relieves the symptoms of high blood pressure, alleviating the patient’s condition for a short time. Only an integrated approach, including treatment with heart medications, diet, and a healthy lifestyle, will help stabilize blood pressure for a long time.

Why is hypertension not treated in Russia?

Hypertension, unfortunately, always leads to heart attack or stroke and death. Only constant use of antihypertensive drugs could allow a person to live.

Now there is a chance to restore blood vessels...

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Source: //otgipertonii.ru/preparaty/papaverin-pri-kakom-davlenii-prinimat/

How does the drug affect blood pressure: increases or decreases

Medicines based on papaverine are intended for the treatment of disorders of the gastrointestinal tract, but they are widely used in the treatment of high blood pressure.

Papaverine hydrochloride and its derivatives have a hypotensive effect and effectively reduce blood pressure.

The positive effect of papaverine on high blood pressure is due to its ability to relax the muscular walls of blood vessels, expanding their lumen. Indirectly, blood pressure decreases due to the accumulation of cycloadenosine monophosphate and a decrease in the content of calcium ions in cells, a slowdown in heart rate and sedation when taking large doses of the drug.

Papaverine, in case of high blood pressure caused by renal colic, reduces it due to its muscle relaxant and analgesic effect on the smooth muscles of the kidneys.

Description and features of the medication

Papaverine or Papaverinum (Latin name), although it is produced from poppy straw, is not classified as a narcotic drug. According to the chemical formula, it is an alkaloid, which was developed in 1848 by the German chemist G. Merck. Refers to vasodilators and myotropic antispasmodics.

Papaverine is used for various diseases and in completely different areas of medicine. Produced in 3 forms:

• ampoules;
• pills;
• candles.

The form of taking medication for high or low blood pressure, as well as for other ailments, can only be prescribed by a doctor, and only a specialist can determine the exact dosage. Before taking, you need to read the instructions and follow them exactly, so as not to harm the body with an overdose and side effects.

The main task of the medication is to eliminate acute signs of the disease, and not to treat it, so Papaverine for pressure can be used once, and not systematically. The entire course of treatment must be prescribed by a doctor and supervised by him.

Papaverine suppositories for blood pressure

Main benefits of Papaverinum:

• multifunctional, acts on several symptoms at once;
• well accepted by most patients;
• suitable for all age categories;
• affordable.

The process of breaking down the drug occurs in the liver, and exit through the kidneys. The drug does not have a negative effect on the mucous membranes of the stomach and intestines, like other medications in this group; this can also be attributed to its advantages.

Papaverinum inhibits phosphodiesterase, which reduces the amount of Ca ions penetrating the smooth muscle cells that make up the blood vessels. As a result, myocytes (vascular smooth muscle cells) stop contracting and the blood vessels stretch. Basically, this effect affects the arteries, but this drug can be used as an antispasmodic for other organs.

"Papaverine" is suitable for all age categories

Instructions for use and dosage

Liquid injection solutions are administered subcutaneously, intravenously, or by injection into large muscles. The dosage for subcutaneous or muscular administration to adults or children over 14 years of age is 10-40 mg (0.5-2 ml) of a 2% solution 2-3 times a day. The rate of intravenous administration should be 3-5 ml/min. Pre-dilute 1 ml of the drug in approximately 20 ml of isotonic solution.

Papaverine solution is used for children under 14 years of age no more than 3 times a day. A single dose is calculated based on the patient’s weight - 0.8 -1 mg per 1 kg of body weight. The maximum amount of active substance, regardless of the administration option, for children under 2 years old should not be more than 20 mg, for 3-4 years old - up to 30 mg, 5-6 years old - 40 mg, 7-9 years old - 60 mg, 10-14 years old - 100 mg.

Adults insert rectal suppositories into the anus, 1-2 suppositories with a frequency of 2-3 times a day, after which it is necessary to lie down for at least 2 hours to prevent fluid from leaking out.

For babies from 6 months of age, suppositories with an active ingredient concentration of 20 mg are divided into several doses into equal parts.

Adults take the tableted drug orally, the daily dose is 120-240 mg, which is divided into 3-4 mg. The average single dosage is from 40 to 60 mg, the maximum single dose is not more than 200 mg, the daily concentration should not exceed 500-700 mg. Children from six months to 2-3 years are prescribed 5 mg, 3-7 years - up to 10 mg, 7-9 years - up to 15 mg, 9-14 years - up to 20 mg.

The duration of treatment with papaverine hydrochloride depends on the nature or intensity of the pain syndrome and the observed results from the use of the drug. Treatment of acute pathological conditions requires the use of the drug for about 5 days, prolonged - up to 21 days.

Contraindications to taking the medication

Papaverine has a number of contraindications for its use. The drug should not be used in the presence of the following diseases and conditions of the body:

• Glaucoma.
• Heart attack.
• Senile age.
• Babies up to 6 months.
• Stroke.
• Hypotension.
• Loss of consciousness.
• Patients over 75 years of age.
• Severe liver disorder.
• Allergy to the components of the medication.
• Atrioventricular block stage 2-3.

Under strict medical supervision, use Papaverine if you have a history of:

• Shock states.
• Hypothyroidism.
• Supraventricular tachycardia.
• Failure of the adrenal glands.
• Chronic kidney disease.
• Age over 65 years.
• Prostate hyperplasia.
• Injuries of the craniocerebral region.

Regarding the use of Papaverine during pregnancy, the medicine has not undergone detailed research, but gynecologists often recommend it for increased uterine tone. This pathological phenomenon is often observed in expectant mothers, which increases the risk of premature birth.

Usually the medicine is prescribed in the first months of pregnancy, as one of the medications in complex therapy. At the last stage of gestation, it is used together with Drotaverine, which makes it possible to prepare the cervix for the birth of a baby.

Side effects

Medicine notes that Papaverine is well tolerated, and the manifestations of adverse symptoms were noted only in isolated episodes, which usually happened when its dosage and prescriptions specified in the instructions were not followed. Usually, unpleasant symptoms were transient in nature or disappeared after the dose was revised.

The expected side effects of the drug can be found in the table below:

In this situation, it is necessary to take activated carbon, thoroughly lavage the stomach and normalize blood pressure parameters.

Features of taking medication during pregnancy and breastfeeding

It has not been reliably established whether papaverine hydrochloride preparations are safe during pregnancy, as well as during breastfeeding. Therefore, caution should be exercised when prescribing medications to expectant and nursing mothers and regularly monitor their physical condition.

Considering that papaverine hydrochloride reduces smooth muscle tone, its use is justified in pregnant women with high uterine tone. More often during this period, women are prescribed rectal suppositories to reduce blood pressure or relieve muscle spasms. In this case, it is necessary to take into account the ability of the drug to dilate blood vessels and increase the speed of blood flow. The use of the drug is contraindicated in children under one year of age, so it is not recommended to take it during breastfeeding.

pharmachologic effect

This medicine primarily has an antispasmodic effect. Thanks to the action of the drug, the amount of calcium ions in muscle tissue decreases, which helps to relax them, and therefore relieve spasm. It is important to take into account that the drug only affects the state of smooth muscles responsible for the contraction of internal organs and vessels of the circulatory system. Papaverine does not affect skeletal or muscle tissue. But it reduces the conductivity of nerve signals to the myocardium, and also reduces the excitability of the heart muscles.

The relaxing effect of the drug only relieves spasms and cannot lead to muscle paralysis. At the same time, papaverine also relieves vasospasm, which not only increases blood pressure, but also disrupts blood circulation in the tissues.

Due to the fact that papaverine is an antispasmodic, it also has anesthetic, sedative and hypotonic effects. The decrease in pressure occurs due to the relief of vascular spasm. They expand and blood flow increases, including in the vessels of the brain, which has a beneficial effect on well-being. However, the main direction of action of the drug is still antispasmodic, not hypotonic, therefore, for hypertension, papaverine is often used as part of a complex treatment of high blood pressure, along with other drugs.

The analgesic effect appears only if the unpleasant symptom is caused by a spasm of smooth muscles; in other cases, the analgesic effect will not appear. When taken in large doses, the sedative effect of the drug appears.

Papaverine tablets

Compatibility with other medications

It has been established that papaverine preparations enhance the effect of alcohol, reduce the hypotensive effect of methyldopa, and can weaken the effectiveness of the antiparkinsonian drug levodopa. The ability of the drug to relieve pain increases when taken together with analgin (metamisone), diphenhydramine (diphenhydramine), diclofenac.

It is possible to enhance the effect of calcium antagonists, substances that block slow and L-type calcium channels (flecainide, etacizin, propafenone, ethmosin), while increasing the concentration of calcium in the myocytes of blood vessels.

When smoking, the metabolism of papaverine in the body accelerates, while the content of the active substance in the blood plasma decreases, therefore, its therapeutic effect decreases. In addition, nicotine can eliminate the property of papaverine to relax the smooth muscle fibers of the muscles of the walls of blood vessels.

Barbiturates enhance the antispasmodic properties of papaverine. Its hypotensive effect is potentiated by the use of antiarrhythmic drugs (reserpine, procainamide, quinidine), tricyclic antidepressants (norepinephrine, serotonin, dopamine).

At what blood pressure is Papaverine prescribed?

Papaverine is an antispasmodic, invented at the beginning of the 20th century. It relaxes smooth muscles, which is why it is often used as a pain reliever. But sometimes the antispasmodic properties of Papaverine are also used in cardiological practice.

Pharmacological properties

The main active component of the drug belongs to opium alkaloids, isoquinoline derivatives. Initially, it was extracted from poppy seeds, which led to the name of the medicine (papaver in Latin - poppy). In therapeutic doses, this chemical compound does not affect the central nervous system, unlike other alkaloids, but has a pronounced antispasmodic effect.

After taking the medicine, the following processes occur in the body:

• photodiesterase synthesis slows down;
• cyclic adenosine monophosphate accumulates in cells;
• the level of calcium ions in muscle tissue decreases;
• muscle fibers relax;
• the spasm is eliminated.

The relaxing effect of the active component is aimed only at smooth muscles.

It includes those muscle groups that are responsible for contracting the internal organs of the respiratory, genitourinary, and digestive systems.

The relaxing effect does not apply to the musculoskeletal system and heart muscle. That is why you can use the drug without the risk of affecting myocardial contractility.

In addition to the antispasmodic effect, Papaverine has the following properties:

1. Painkillers. The effect is a consequence of muscle relaxation. But, unlike analgesics, the medication eliminates spasm - the cause of pain and functional disorders in the functioning of internal organs.
2. Hypotonic. Papaverine for high blood pressure is used in combination with other drugs. In its own form, it only slightly reduces blood pressure - due to the expansion of the lumen of blood vessels.
3. Sedative. It is observed only when using the drug in high doses. In this case, the opium alkaloid reduces the conduction of nerve signals.

The antispasmodic is available in the form of tablets, injection solution and rectal suppositories. It can be given to children starting from 6 months of age.

Hypertensive crisis

Papaverine for pressure that threatens the development of a hypertensive crisis is used in combination with Dibazol. In this case, both drugs are administered intravenously or intramuscularly. The following dosage is recommended: antispasmodic – 2 ml of 2% solution (one ampoule), Dibazol – 3-5 ml of 1% solution.

//www.youtube.com/watch?v=qh9LqyUiWsM

For intramuscular injection, choose the upper outer surface of the thigh or shoulder. The needle should be perpendicular to the surface of the skin. After the injection, the injection site is wiped with an anesthetic.

Initially, the patient's blood pressure rises sharply and then decreases to a normal value. In case of critical condition, Analgin is added to the combination to enhance the analgesic effect.

Hypotension and other contraindications

Papaverine is prohibited for low blood pressure. Other contraindications include:

• age younger than 6 months and older than 65 years;
• atrioventricular block;
• adrenal insufficiency;
• prostatic hyperplasia;
• hypothyroidism;
• cardiopalmus;
• severe pathologies of the kidneys and liver;
• glaucoma;
• state of shock;
• recent traumatic brain injury.

Possible side effects include drowsiness, hypotension, arrhythmia, and blood clots. Occasionally, nausea, vomiting, and allergic reactions occur.

Prices in pharmacies

Russian pharmacies offer tablets of domestic and Belarusian production. One package (40 pcs) will cost the consumer 11 rubles. Suppositories cost an average of 78 rubles, solution for injections – 23 rubles.

In Ukrainian pharmacies you can buy tablets from a Kharkov company for 17 UAH. For an injection solution from Darnitsa you will have to pay 55 UAH.

Source: //dawlenie.com/papaverin-pri-davlenii.html

The drug belongs to the group of myotropic antispasmodics and has a relaxing effect on the smooth muscles of internal organs and the vascular wall. Most people suffering from hypertension are interested in the question: can Papaverine really lower blood pressure? The answer will be positive; this medicine can be used by hypertensive patients for therapeutic purposes.

“Papaverine” is produced in several dosage forms:

• suppositories;
• pills;
• injection.

The solution for injections is dispensed from pharmacies in glass ampoules of 2 milliliters, ten pieces each in blister packs. The drug contains one active ingredient – ​​papaverine hydrochloride.

Medicinal properties

According to the instructions for use, Papaverine injections have a relaxing effect on the smooth muscles that line the internal organs. In addition, the drug affects blood vessels, due to which the injections slightly reduce blood pressure.

“Papaverine” has a mild calming effect. After using the solution intramuscularly, the pharmacological effect appears after about half an hour and lasts up to six hours.

According to the instructions for use, Papaverine blood pressure tablets have a pronounced antispasmodic and analgesic effect. Through its vasodilating effect, the medication may have a slight effect on blood pressure levels.

Once in the general bloodstream, the active component of the drug inhibits the activity of the phosphodiesterase enzyme, which leads to a decrease in calcium in the body and disrupts the contractile function of smooth muscles, helping to relax them.

Papaverine perfectly neutralizes spasms of the intestines, as well as the uterus, gall bladder and bladder, respiratory organs, kidneys and blood vessels. At the same time, the motor activity of relaxed muscles is completely preserved.

When are Papaverine injections prescribed?

Injections are prescribed to people with the following conditions and diseases:

1. Angina pectoris (pain in the heart area caused by insufficient blood supply to the heart muscle).
2. Exacerbation of cholecystitis (inflammation of the gallbladder is one of the most common complications of cholelithiasis).
3. Increased uterine tone in pregnant women.
4. Renal or biliary colic (inflammation of the gallbladder is one of the most common complications of gallstone disease).
5. Angiospasm (narrowing of blood vessels, small arteries and capillaries, resulting in impaired blood circulation and tissue fluid exchange).
6. High temperature in adults and children.
7. Colitis (inflammatory disease of the colon mucosa).
8. Cholangitis (inflammation of the bile ducts due to infection entering them from the gallbladder, intestines, blood vessels (more often) or through the lymphatic tract).
9. Pylorospasm (a pathological condition that manifests itself in childhood).

Indications for use of tablets

The drug is especially effective in the following cases:

1. Inflammation of the gallbladder.
2. Spasms of smooth muscles of the gastrointestinal tract.
3. As part of complex therapy for spastic colitis (inflammation of the mucous membrane of the large intestine, accompanied by insufficiency of peristalsis).
4. Renal colic (an acute attack of pain in the lumbar region, caused by a sudden disruption of the outflow of urine from the kidney and impaired blood circulation in it).
5. Increased uterine tone.
6. Bronchospasm as part of complex treatment (a pathological condition that occurs when the smooth muscles of the bronchi contract and their lumen decreases).
7. Spasm of the blood vessels of the brain.
8. Angina pectoris.
9. Stroke (acute cerebrovascular accident leading to persistent focal brain damage).
10. Heart attack (a focus of ischemic necrosis of the heart muscle, developing as a result of an acute violation of the coronary circulation).
11. Pylorospasm (contraction of the gastric pylorus (the transition zone of the stomach into the duodenum), observed mainly in infants, is caused by functional disorders of the neuromuscular apparatus of the pyloric part of the stomach).

Papaverine suppositories have the same indications for use.

Contraindications of the solution

Before starting to use the drug, it is important to carefully read the instructions, since the “Papaverine” solution has a number of contraindications for use:

1. Severe hypotension (a decrease in blood pressure by more than twenty percent from the original/usual values).
2. Bradycardia (decreased heart rate).
3. Individual intolerance.
4. Severe liver and kidney diseases.
5. Children up to six months old.

It must be remembered that “Papaverine” cannot be used at low blood pressure. It is necessary to use the injection solution with extreme caution in patients over sixty years of age, since there is a likely risk of hyperthermia.

Restrictions on tablets and suppositories

The medication in both forms of release is prohibited in the following cases:

1. Children's age up to six months.
2. Significant reduction in blood pressure.
3. Individual intolerance to the drug.
4. Acute renal or liver failure.
5. Glaucoma (a large group of eye diseases characterized by a constant or periodic increase in intraocular pressure above the tolerable level).
6. Comatose states (an acutely developing severe pathological condition characterized by progressive depression of central nervous system functions).

What pressure does Papaverine cause?

The medication acts on the internal organs, ensuring their relaxation. Due to the increase in lumen, the pressure in the capillaries becomes somewhat less, because the total capacity of the arteries and veins increases.

The drug is not used for low blood pressure, as this will lead to an even greater hypotensive effect. “Papaverine” has an effect only on smooth muscles and absolutely no effect on striated muscles.

The drug does not affect the contractility of the heart or skeletal muscles. There is also no muscle relaxation, which means there will be no feeling of weakness or other negative effects.

Using the drug for high blood pressure

To reduce blood pressure, the patient is injected intramuscularly with two medications at once - a pressure injection “Papaverine” and “Dibazol”, this is done for the greatest effectiveness.

Both drugs have a hypotensive effect. After administering the drug in injections, the patient’s condition improves and unpleasant symptoms disappear, such as:

• headache;
• dizziness;
• weakness.

Blood pressure may decrease not only in patients who suffer from hypertension, but also in people exposed to stressful situations.

Tablets are used in a dosage of 40 to 60 milligrams two or three times a day, washed down with water. The intravenous and intramuscular injection of “Papaverine” for pressure allows you to achieve the desired effect faster, so the dosage of the drug is reduced by 10 mg. The time interval between procedures should be at least five hours.

As for suppositories, they should be inserted into the anus twice a day. After use, it is recommended to remain in a horizontal position for two hours so that the medicine does not leak out.

The medicine “Papaverine” is well tolerated by people, but still in rare situations with increased sensitivity or exceeding the dosage it can provoke the following unpleasant consequences:

1. Dizziness.
2. Intestinal obstruction (a syndrome characterized by partial or complete disruption of the movement of contents along the digestive tract and caused by a mechanical obstruction or impaired intestinal motor function).
3. Flatulence (a pathological condition of the body that occurs as a result of excessive gas formation and accumulation of gases in the gastrointestinal tract).
4. Lethargy.
5. Drowsiness.
6. Decreased blood pressure levels.
7. Hyperhidrosis (a disease that causes excessive sweating).
8. Impaired liver function, as well as an increase in the activity of organ transaminases.

After stopping the use of the drug or reducing the dosage of “Papaverine” (it is often prescribed for blood pressure), all adverse reactions disappear.

If the recommended concentration of the drug is greatly exceeded, a person may experience a drop in blood pressure and the appearance of acute vascular insufficiency. In addition, poisoning intensifies the above-described negative effects.

Compatibility with other drugs

According to the instructions for use, Papaverine injections, as well as tablets and suppositories, reduce the effectiveness of the following medications - Methyldopa and Levodopa. Barbiturates significantly enhance the antispasmodic effect.

An increase in the hypotensive effect is achieved with the use of tricyclic antidepressants:

1. “Quinidine.”
2. "Reserpine".
3. “Procainamide.”

“Papaverine” reduces the pharmacological effect of “Dopegite”.

Peculiarities

You cannot combine alcoholic beverages and therapy with this medication. Papaverine injections should be prescribed with extreme caution to people with low blood pressure, as well as those who have recently suffered a traumatic brain injury.

For persons with impaired functioning of the kidneys, as well as the liver and thyroid gland, it is important to consult a doctor before starting treatment.

The use of suppositories during pregnancy and lactation is prohibited, since there is no reliable information about the safety of “Papaverine” for the baby. The active component of suppositories may interact with drugs from other therapeutic groups, so you should consult a medical specialist about their possible use.

There is no reliable information regarding the effect of candles on the functional activity of the cerebral cortex, and therefore it is not recommended to perform work that requires increased attention and speed of psychomotor reactions.

Generics

“Papaverine” has a number of substitute drugs to reduce blood pressure:

1. “Papazol.” Its structure contains two active ingredients - papaverine and dibazole in a one to one ratio. The medicine helps expand capillaries in the brain, which helps lower blood pressure and improve blood microcirculation.
2. “Andipal.” This medication contains several active ingredients - papaverine, dibazole, phenobarbital and analgin. The drug is allowed to be used by hypertensive patients to reduce blood pressure and eliminate unpleasant symptoms.
3. “Biospa” is used for spasms of smooth muscles, as well as headaches and high blood pressure. Adult patients can take 50 to 60 milligrams orally three times a day, while 60 mg injections can be administered one to two times a day.
4. “No-Shpa” is used to neutralize spasms of various origins. It is often used during childbirth to relieve uterine spasms. The daily dosage is 130 grams, this concentration should be divided into two or three applications.
5. “Drotaverine” is widely used for spasms of smooth muscles, as well as colic, to slightly reduce pressure. Prescribed for use at 0.04 or 0.08 milligrams one to three times a day.

Papaverine is typically used to relieve spasms and reduce blood pressure. It is necessary to observe the exact dosage, without exceeding it yourself to avoid poisoning. Patients who have an individual intolerance to substances in the composition should avoid using this medicine.

How to store the drug

“Papaverine” in injections can be purchased at pharmacies without a prescription from a medical specialist. Ampoules should be kept in a cool place. If the integrity is damaged, the drug cannot be used for injection. Suppositories and tablets have the same storage conditions as the injection solution.

Opinions

Reviews of “Papaverine” (it helps well against blood pressure) can be found on various forums and Internet resources, since a wide range of therapeutic effects of the active substance helps evaluate its effectiveness for a large audience of patients with various ailments.

Proctologists and their patients speak positively about the drug, since “Papaverine” is used as a complex conservative therapy for hemorrhoids.

The use of a medicinal drug in the form of rectal suppositories helps to facilitate bowel movements, partly helps to neutralize pain, and also eliminate bleeding from dilated hemorrhoids.

Source: //FB.ru/article/449702/papaverin-ot-davleniya-instruktsiya-po-primeneniyu-protivopokazaniya-otzyivyi

Contraindications and overdose

It is prohibited to use papaverine to reduce blood pressure and treat muscle spasms in patients with individual intolerance to the active or auxiliary components of the drug. The main contraindications also include:

• age under one year or over 75 years, with a risk of increased body temperature (hyperthermia);
• in comatose states, suppression of the functioning of the respiratory system;
• periodic or constant increase in intraocular pressure (glaucoma);
• Cavernous administration of the drug is not recommended for Peyronie's disease;
• high intracranial pressure;
• atrioventricular block, in which there is a violation of the conduction of electrical impulses from the atria to the ventricles;
• heart failure;
• liver dysfunction.

The risk of overdose increases with the administration of high doses of papaverine, in the presence of pathological lesions of the liver, excretory, respiratory or cardiovascular systems. In this case, patients experience drowsiness, weakness, low blood pressure, double vision (diplopia).

If signs of overdose appear, you must stop taking the drug; if you used tablets, rinse your stomach with activated charcoal dissolved in milk. To eliminate the complications that arise, symptomatic and supportive therapy is indicated. Measures should be taken to restore normal pressure.

A special feature of papaverine is its effect on the cavernous bodies of the penis. To eliminate prolonged painful erection caused by taking the drug, hemoaspiration and surgery to bypass the vessels of the penis are performed.

Indications for use

The antispasmodic is used for hypertension, cerebral vascular spasms, and ischemia of the heart muscle. Indications also include narrowing of the lumen of blood vessels in the bronchi, endarteritis, spasms in various parts of the digestive tract. Often the medication is used before the introduction of anesthesia, as well as during a hypertensive crisis.

The wide range of action of the drug allows it to be included in the complex therapy of pathologies of the cardiovascular system. It does not have a pronounced hypotensive or hypertensive effect, but can provide significant support in eliminating the consequences of blood pressure surges.

Analogues of the drug

The most well-known muscle relaxants, antispasmodics and antihypertensive drugs, with an effect similar to papaverine, are Andipal, Belalgin (active substance metamizole sodium), No-shpa (drotaverine hydrochloride), similar in composition to Spazmalgon and Renalgan.

The combined drugs Andipal and Belalgin contain a non-steroidal anti-inflammatory substance, have a pronounced analgesic, vasodilator, antispasmodic effect, and have a weak antipyretic and antihypertensive effect.

No-spa is an antispasmodic drug that has a myotropic effect on the smooth muscle tissue of the walls of blood vessels and hollow organs, promoting a moderate expansion of the lumen of blood vessels without affecting the nervous system.

Spazmalgon and Renalgan include 3 components: metamizole sodium, fenpiverinium bromide, pitofenone. These medications relieve inflammation and pain, eliminate muscle spasms, lower body temperature, and block the neurotransmitter acetylcholine.

Papaverine hydrochloride is completely absorbed in the intestine and acts very quickly. Its dosage forms are available from pharmacies only with a prescription. Therefore, before using the drug for blood pressure, you should consult your doctor and carefully read the instructions.

Reviews

Pigareva A.V.

A very good, one might say, reliable pharmaceutical drug, time-tested many times, and inexpensive. It perfectly relieves spasms of smooth muscles and gives a quick clinical effect. There is a side effect, but it occurs extremely rarely. The drug can be used not only for headache crisis or as part of complex therapy for essential hypertension, but also for various obstetric pathologies, for urolithiasis, as well as for gastrointestinal spasms of various levels.

Glebova E. V.

Papaverine is an immediate-acting antihypertensive drug that is considered relatively safe for pregnant women. It helps to effectively relieve hypertonicity of the uterine walls in the presence of a threat of miscarriage. Since the wall of the uterus is represented mainly by muscle fibers, and Papaverine works by acting specifically on the muscle structure, it helps to relieve pain symptoms with maximum efficiency in the early stages of pregnancy.

Korenko I. V.

An excellent and effective antispasmodic, and completely inexpensive. It has a pronounced antispasmodic, vasodilator and hypotensive effect. Can be used by both pregnant women and children from 6 months. It is widely used in hospitals to relieve spasms of the smooth muscles of the visceral organs. Smoothly relieves an attack of blood pressure and is easily tolerated by patients. Of course, there are undesirable side effects, like all effective drugs, but with the competent advice of the attending physician, they almost never occur.

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Hypertension